BIBU 1361 dihydrochloride Catalog No.:M21988-C CAS Number: 73069-27-9

CAS Number: 73069-27-9

RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase

Dexamethasone acetate is an anti-inflammatory glucocorticoid

Smiles: OCC1C=C(O)C2=C(C=1)C(=O)C1C=CC=C(O)C=1C2=O

BIBU 1361 dihydrochloride Catalog No.:M21988-C CAS Number: 73069-27-9BIBU 1361 dihydrochloride is a selective inhibitor of epidermal growth factor receptor (EGFR) kinase with an IC50 value of 0. 038 0. 007 M [1, 2]. The EGFR signaling pathway is associated with multiple intracellular signaling events that promote proliferation and survival. It plays a key role in the progression of glioblastoma multiforme (GBM) . In glioma cells, EGFR signaling can induce the phosphorylation of Akt, Erk1 2 and STAT3. BIBU 1361